Maybe, maybe not.
Tyre can save your itineraries (route files) as different file types, including: *.itn (TomTom Itineraries), *.ov2 (TomTom Points of Interest), *.kml / *.kmz (Google Earth), *.rte / *.rt2 (OziExplorer), *.gpx (Garmin GPS Exchange) and *.csv (Garmin Points of Interest).
Most other systems do not accept itn files or kml files. Maybe they accept gpx files, because that file type is common for GPS files.
So, if your system accepts gpx files, you can use Tyre.
Since version 5.43 Tyre is fully compatible with Garmin devices. That means: if you connect a Garmin device to your computer, Tyre will notice and switch to 'Garmin mode'.
Since version 6.40 Tyre is fully compatible with Interphone GPSBike devices. That means: if you connect such a device to your computer, Tyre will notice and switch to 'Interphone mode'.
To learn more about using the 'Interphone mode', we have made a short manual that can be downloaded here: Interphone Manual
If you are using iGo software, you can use Tyre this way: save your route in the Google KML format. If necessary, create a folder 'userdata' on your SD-card, with a subfolder 'route' in it. Copy your route (in KML format) into that folder.
If you are using Navigon software, you can use Tyre this way: save your route in the Google KML format. Then copy the file to the proper folder on your navigation device.